For the second straight game, Anthony Santander — who before this series had never played first base in the major leagues — started at first, while Ryan Mountcastle did not play in the field for the second day in a row.

Before the game, manager Brandon Hyde said he was simply giving the 6-foot-3 power hitter a rest. “I’m sure he’ll be in the game at some point,” Hyde said Tuesday afternoon.

Mountcastle not only got into the game Tuesday night, he tallied six bases in his two plate appearances, including a 433-foot, two-run home run in the sixth inning that gave the Orioles a 7-3 lead they would not relinquish.

That marked the second homer from a Ryan hitting in the No. 9 spot for Baltimore as lefty Ryan O’Hearn went deep in the second inning. Once Angels right-hander Chase Silseth was replaced by a lefty in the fourth, Mountcastle entered the game and left his mark.

With the win in front of an announced crowd of 13,244, the Orioles improved to 27-15 while the Angels fell to 22-21.

The Angels overpowered the Orioles Monday night as Shoehi Ohtani reached base five times, but neither Ohtani nor Angels co-star Mike Trout reached base Tuesday. It marked only the second time this season that neither reached base in a game in which they each batted at least four times.

The Angels took a lead on the first batter of the game as Mickey Moniak, the first overall pick of the 2016 MLB draft, homered off Dean Kremer. However, Kremer settled down after the first inning, retiring nine straight batters at one point. He threw 95 pitches and allowed three runs on six hits in 5 2/3 innings.

Orioles starting pitchers have struggled going deep into games this year, but Kremer’s start was his sixth straight of at least five innings.

The Orioles’ offense, meanwhile, scored four runs against Silseth in his 3 1/3 innings. After loading the bases but not plating any in the first frame, the Orioles tied the game at 1 on O’Hearn’s solo shot. Then, in the fourth, Baltimore scored three on the strength on hits from Gunnar Henderson, Terrin Vavra, Jorge Mateo and Mountcastle before a three-run sixth by Baltimore gave it a 7-3 lead.

Bryan Baker, Cionel Perez and Yennier Cano did not allow a run through 3 1/3 innings for the bullpen in securing the win.

Angels at Orioles

Wednesday, 6:35 p.m.

TV: MASN2

Radio: 97.9 FM, 101.5 FM, 1090 AM

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