Yorgos Lanthimos’ “Poor Things” won the Gold Lion, the top prize, at its Venice world premiere and now looms as an Oscar favorite.

A bizarre, unsettling, one-of-a-kind odyssey, it gifts Emma Stone with not just a chance for a second Best Actress Oscar but buzz as one actor ready for anything.

Stone’s Bella is brought to life as a late 19th century Frankensteinian brain-switching experiment by Willem Dafoe’s mad doctor (he resembles the classic Hollywood monster).

A satirical sex comedy and feminist revenge tale, “Poor Things” boasts frequent, unabashed full-out nudity as it traces Bella’s rapid evolution from childhood to maturity.

“We had to be confident like the character and have no shame,” Lanthimos, 50, said of his film which costars Mark Ruffalo and Ramy Youssef. “And Emma had to have no shame about her body, nudity, doing those scenes. She understood that right away.”

This is the fourth teaming of the Greek writer-director and his unabashedly American star.

It works, Stone, 35, said in a virtual press conference, because, “I think we just truly love each other. We really understand each other and get along really well.

“I feel I can completely trust him as a director and collaborator and that’s so rare as an actor, to be able to just totally give yourself over and know that you’re being protected.

“Why I love working with him time and again is he loves to build kind of a company. Not just the actors but the crew. It’s the same people that keep coming back — and you feel safer with everybody,  closer to everybody because of that. There’s a real shorthand.”

Bella’s epic transformations, from a newborn’s curiosity to a grown woman freeing herself from conventions, were accomplished, Stone said, “Just by trying to remove as much judgment and shame as possible, because it was actually more of an undoing than it doing.

“Obviously, the physicality and the language and all of that was something that we worked on pretty extensively — because we needed to. We needed to understand her stages as the film progresses and the story progresses.

“But more than anything, it was just letting go because Bella is pure joy and curiosity and doesn’t have shame. Doesn’t have trauma.

“It’s hard to find an adult that hasn’t gone through things and has certain Pavlovian responses, certain judgment about themselves or others.

“That was the great gift of playing her with that: She just lives in a place of discovery. So in my mind, that was the biggest part of preparation to play her.”

“Poor Things” opens Dec. 15