Celtics coach Joe Mazzulla ruled out Jayson Tatum and Marcus Smart before Wednesday’s home tip-off against the Raptors.

Both players had been listed as questionable on the team’s injury report. Smart is dealing with a neck spasm, while Tatum has a left hip contusion, per the Celtics. Tatum played one of his worst offensive games of the season Tuesday against the Sixers, scoring 19 points on 7-of-20 shooting and going a team-worst minus-13.  After the game, Smart, who had 17 points, said he played with a pinched nerve.

Veteran big man Al Horford (lower back) was ruled out earlier Wednesday.

Jaylen Brown (lower back) and Robert Williams (knee) are expected to start versus Toronto after sitting out Tuesday’s close loss at Philadelphia. Raptors guard Gary Trent Jr. is available after being listed as questionable with back spasms.

Wednesday’s game will be the first of back-to-back games against the Raptors. The Celtics will host Toronto again Friday night before closing out the regular season Sunday versus Atlanta.