A large-scale response is underway in Sacramento after a REACH Air Medical Services helicopter crashed onto Highway 50, shutting down eastbound traffic Monday night.

Multiple crew members were taken to area hospitals, according to a statement from REACH Air Medical Services.

No patient was on board, the company said.

The helicopter appeared to have just lifted off from UC Davis Medical Center when it crashed, according to flight-tracking data.

California Highway Patrol said it will be working with the National Transportation Safety Board and Federal Aviation Administration to investigate and decide when the wreckage can be moved off the freeway.

"We are in the process of determining the details of this situation, as well as the condition of the REACH crew involved," the company said.

This is a developing story. Please check back for updates.